Non-Hodgkin lymphoma research (excluding all B cell lymphoma) in Malaysia: A review

Posted Posted in Review Articles

Authors: Kean Ghee Lim, Sunil Pazhayanur Venkateswaran, Afshan Sumera, Ismail Abdul Sattar Burud, Purushotham Krishnappa, Nabeel Ibraheem Jaafar.

ABSTRACT

Introduction: Lymphoma is a diverse group of malignant proliferations that arise as discrete tissue masses. The 5th edition of the World Health Organization classification of Tumours of Haematopoietic and Lymphoid Tissues was released on 22nd June 2022. The WHO-HAEM5 classification of Mature T and NK neoplasms is further subclassified into various categories which are detailed in this review.

Methods: A search was conducted using bibliographic databases, various repositories, and the Clinical Research Centre website retrieving journal articles, conference proceedings, book Chapters, guidelines, and thesis. The search terms used were Malaysia AND lymphoma.

Results: The search earmarked a total of 561 papers. There were nine case series retrieved from 1967 to 2022. The site, age distribution, prognostic markers, and the various subclassification of NK/T cell lymphomas were studied. The gastrointestinal tract was the commonest site for extranodal lymphomas. Prognostic markers associated were EBV, C-MYC protein and staining for CD2, CD3, CD20, CD56, and CD57 antigens. For anaplastic large cell lymphoma (ALCL), CD30 (Ki-1) and ALK antigens were noted as important. The use of 18F-Fluorodeoxyglucose (FDG) positron emission tomography-computed tomography (PETCT) has emerged as an important investigation. Various chemotherapeutic regimens, surgical interventions where necessary and autologous peripheral blood stem cell transplantation when indicated are the mainstay of treatment.

Conclusion: Research on NK/T cell lymphoma, including ALCL, has been ongoing in recent years. This review adds on to the existing literature on lymphoma in Malaysia that can lead to further research, into the diagnosis and treatment of lymphoma in Malaysia and around the world.

Keywords: Lymphoma, NK/T cell, anaplastic large cell lymphoma (ALCL), Malaysia

Citations: IeJSME 2023 17 (2): 34-52

DOI: https://doi.org/10.56026/imu.17.2.34

Synchronous Clinical Simulation: An Effective Teaching Modality in Medical Education During COVID-19 and Beyond

Posted Posted in Original Article

Authors: Thiruselvi Subramaniam, Mohammad Arshad Ikram, Shamala Ramasamy.

ABSTRACT

Background: The spread of COVID-19 forced many countries including Malaysia to switch from on-campus learning to exclusively online learning. The modality of the synchronous session allows the learners to interact with the instructor and obtain instant feedback. The purpose of this study was to evaluate the effectiveness of synchronous simulation among medical students in clinical years in the absence of hospital-based clinical education.

Methods: This was a prospective observational study involving 54 clinical year students, conducted in the simulation lab at International Medical University. Scenarios for each session were built around clinical skills targeting specific learning outcomes. The perception of the simulation session was evaluated using a 5-point Likert Scale. Synchronous debriefing followed each simulated session allowing active participation by all students. Focus group discussion was conducted among 6 students who volunteered representing online participants to obtain feedback on their learning experience.

Results: The highest mean scores were obtained for the items referring to team communication (4.09±0.734), debriefing (4.06±0.811) and timetabling (3.92±1.007). Results from the focus group discussion revealed that: simulated sessions assisted in application of knowledge by observing their peers; the repetitive process of observing and performing was preferred over observing per se; observing the performance of peers from the same cohort was preferred, and critiques on technical logistics were reported.

Conclusion: The synchronous simulation sessions were well received by the students. It is believed that this will be a novel teaching modality to adopt even after the passing of the pandemic.

Keywords: Clinical teaching, medical student, medical education, simulation, synchronous, teaching modality.

Citations: IeJSME 2023 17 (1): 02-08

DOI: https://doi.org/10.56026/imu.17.1.2

A Cross-Sectional Study on the Knowledge, Attitude and Practice of Hand Hygiene among Adults in the Chowrasta Market, Penang

Posted Posted in Original Article

Authors: Woan Ching Chang, Elvina Yuh Harn Lau, Yi Xuan Goh, Yen Wen Tan.

ABSTRACT

Background: The community plays a crucial role in practising effective hand hygiene to prevent disease transmission. Several studies conducted on hand hygiene practices among healthcare practitioners show positive outcomes in decreasing disease transmission particularly during the COVID-19 pandemic. However, studies related to hand hygiene among adults in the local communities are scant.

Aim:  This study aimed to determine 1) the level of knowledge, attitude, and practice of hand hygiene, and 2) the relationship between demographic factors and hand hygiene practice among adults in a local community in Penang.

Methods: This was a cross-sectional quantitative survey combined with direct observation of hand hygiene practice. A self-administered questionnaire on knowledge and attitude towards hand hygiene, and an observational checklist of hand hygiene practice were adapted to measure the variables studied. Non-random quota sampling technique was used to recruit the required 398 sample size.

Results: The study found that the level of knowledge using an internationally commonly used 12 item questionnaire was good. Attitude towards hand hygiene measured on another 7 item questionnaire was also good. A majority of the participants (73.9%) had a good level of hand hygiene practice. No significant relationship was found between age, gender, level of education, and hand hygiene practice.

Conclusion: Local health authorities are urged to continue to emphasise to the public on the importance of hand hygiene to reduce disease transmission in the community. Further studies are recommended to explore the possible barriers that hinder people from adopting good hand hygiene practice.

Keywords: adults, attitude, hand hygiene, knowledge, practice

Citations: IeJSME 2023 17 (1): 09-18

DOI: https://doi.org/10.56026/imu.17.1.9