Delivering drugs to farmed animals using controlled release science and technology

Posted Posted in Review Articles

Author: Michael John Rathbone

ABSTRACT

This article presents an overview of long acting products used in animal health, production and reproduction. The topic represents a niche field of controlled release that few formulation scientists become specialists and experts in, but it is a field which has made significant contribution to the area of controlled release technology, and one which is of major importance to human kind due to their dependence on farmed animals as a source of hide, protein, milk and eggs.

Keywords: Intravaginal drug delivery, veterinary drug delivery, animal health, controlled release, oestrous control.

Citation: IeJSME 2012: 6 (Suppl 1): S118-S128

DOI: https://doi.org/10.56026/imu.6.Suppl1.S118

Shock in children

Posted Posted in Review Articles

Author: Davendralingam Sinniah

ABSTRACT

Shock, a major cause of morbidity and mortality in children, is the the most anxiety-provoking emergency that needs to be addressed urgently and effectively by the attending paediatrician. It is a state where the metabolic demands of the tissue are not met due to circulatory dysfunction. Unlike adults, hypotension is a very late feature of shock in children. As the child’s condition worsens, the clinical presentation of the different causes of shock become similar, and nullify any aetiological differences. Regardless of the type of shock, the final common pathway is inadequate tissue perfusion and oxygen supply to meet cellular demands. Delayed recognition and treatment result in progression from compensated reversible shock to uncompensated irreversible shock with widespread multiple system organ failure to death. This paper reviews the physiological basis, and pathophysiological classification of the various types of shock and their respective aetiologies. The clinical features of the different types of shock are described, and current diagnostic and therapeutic strategies are applied for the most effective and appropriate treatment for resuscitating the child in shock. A strong index of suspicion, early recognition, timely intervention and transfer to an intensive care unit are critical for successful outcomes in the management of paediatric shock.

Keywords: shock, child, aetiology, treatment, management.

Citation: IeJSME 2012: 6 (Suppl 1): S129-S136

DOI: https://doi.org/10.56026/imu.6.Suppl1.S129