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Dengue is the most rapidly increasing arthropod-borne disease globally. The disease burden has increased exponentially, doubling almost every decade from the estimated 8.3 million cases in 2010 to about 58.4 million cases in 2013.1 The number of countries reporting dengue has also increased. Before 1970, less than 9 countries reported dengue but now it has been reported in more than 100 countries worldwide. It is transmitted by two species of Aedes mosquito, Aedes aegypti and Ae. albopictus.

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Online Open-Access Electronic Publications

International E-Journal of Science, Medicine & Education (IeJSME) is established by the International Medical University, Malaysia to provide a forum for disseminating quality articles of important scientific merit to the international research community on the three area of Basic Science, Clinical Science and Medical Education Research. The IeJSME is a tri-annual journal.

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Review
Neuroendocrine carcinoma of the cervix: Review of classification and current developments in diagnosis and management
Kavitha Nagandla, Sharifah Sulaiha, Sivalingam Nalliah, Norfadzilah Mohd Yusof
Neuroendocrine carcinoma of the female reproductive tract are a heterogeneous group of rare neoplasms posing both diagnostic and therapeutic challenges. The recent classification by WHO includes neuroendocrine carcinomas (NECs) and neuroendocrine tumours (NETs). NECs are the poorly differentiated small cell carcinoma (SCNEC) and large cell neuroendocrine carcinoma (LCNEC), while well-differentiated NETs include typical carcinoids (TC) and atypical carcinoids (AC). Majority of these tumours have an aggressive clinical course and published data is supportive of multi-modal therapeutic strategies. Etoposide/platinum based chemotherapy is commonly advocated. Histopathological categorisation and diagnosis are paramount to guide therapy. Well-differentiated carcinoid and atypical carcinoid tumours should be managed similar to gastroenteropancreatic neuroendocrine tumours. This review discusses the current classification, clinicpathologic characteristics and advances in the diagnostic evaluation and the treatment options of neuroendocrine carcinoma of the cervix.

International eJournal of Science Medicine and Education (IeJSME) publishes fully open access articles, which means that all articles are available on the internet to all users immediately upon publication. Non-commercial use and distribution in any medium is permitted, provided the author and the journal are properly credited.

IeJSME also operates under the Creative Commons Licence CC-BY-NC-ND. This allows for the reproduction of articles, free of charge, for non-commercial use only and with the appropriate citation information. All authors publishing with the IeJSME accept these as the terms of publication.

Overview

International e-Journal of Science, Medicine & Education (IeJSME) is a tri-annual journal. It is established by the International Medical University, Malaysia, with the intention to provide a forum for disseminating quality articles of important scientific merit to the international research community on the three areas of:

  • Basic Science,
  • Clinical Science (including Healthcare Quality and Service Research) and,
  • Medical Education Research.

All manuscripts are subjected to the process of peer-review and if accepted, will be published solely in an open-accessed electronic format in IeJSME website to enable unlimited access for everyone in the international community.

The e-Journal is committed to providing decisions on submitted manuscripts within three months of their receipt. Articles of special importance will be considered for early pre-Issue publication with agreement from the authors.

IeJSME will strive to adhere to the code of conduct and guidelines set by The Committee on Publication Ethics (www.publicationethics.org.uk) in all its endeavors. IeJSME will also apply to National Library of Medicine (NLM) to be indexed by Medline whenever it becomes eligible to do so.

We welcome submission of

  • Original articles of primary research conducted,
  • Review articles that offer in-depth discussion on matters of recent topical concerns,
  • Research Notes, a special section dedicated to (A) publication of preliminary observations of scientific importance, and (B) publishing research findings of undergraduate healthcare students (e.g. medical, nursing, pharmacy and dental students) with the view to encouraging research thinking and culture, and
  • Correspondence that comments on published articles in IeJSME
  • For the purpose of this journal, only Case Reports of exceptional merit are considered for publication.

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